Nitroso Impurity 2

CAS No: NA
Chemical Name:
N-(6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)-N-(5-(4-nitrosopiperazin-1-yl)pyridin-2-yl)nitrous amide
Molecular Formula:
C24H27N9O4

Nitroso Impurity 1

CAS No: NA
Chemical Name:
N-(6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)-N-(5-(piperazin-1-yl)pyridin-2-yl)nitrous amide
Molecular Formula:
C24H28N8O3

Nitroso Impurity 4

CAS No: NA
Chemical Name:
5-(4-Nitrosopiperazin-1-yl)pyridin-2-amine
Molecular Formula:
C9H13N5O

Nitroso Impurity 3

CAS No: 2089333-12-8
Chemical Name:
1-(6-Nitropyridin-3-yl)-4-nitrosopiperazine
Molecular Formula:
C9H11N5O3

Impurity-9

CAS No: 39856-50-3
Chemical Name:
 5-Bromo-2-nitropyridine
Molecular Formula:
C5H3BrN2O2

Impurity-8

CAS No: 1013916-37-4
Chemical Name:
2-chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one
Molecular Formula:
C13H14ClN3O

Impurity-10

CAS No: NA
Chemical Name:
5-bromo-2-chloro-N-cyclopentylpyrimidin-4-amine
Molecular Formula:
C9H11BrClN3

Impurity-11

CAS No: NA
Chemical Name:
5-bromo-N2,N4-dicyclopentylpyrimidine-2,4-diamine
Molecular Formula:
C14H21BrN4

Impurity-12

CAS No: NA
Chemical Name:
N2,N4-dicyclopentylpyrimidine-2,4-diamine
Molecular Formula:
C14H22N4

Impurity-7

CAS No: 2242625-36-9
Chemical Name:
(Z)-3-(2-chloro-4-(cyclopentylamino)pyrimidin-5-yl)but-2-enoic acid
Molecular Formula:
C13H16ClN3O2

 Chlorobromo Impurity 

CAS No: 1016636-76-2
Chemical Name:
6-Bromo-2-chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one
Molecular Formula:
C13H13BrClN3O

Piperazine Acetyl impurity

CAS No: 1974279-20-3
Chemical Name:
6-acetyl-8-cyclopentyl-5-methyl-2-(5-(4-nitrosopiperazin-1-yl)pyridin-2-ylamino)pyrido[2,3-d]pyrimidin-7(8H)-one
Molecular Formula:
C26H31N7O3

Piperazine Nitroso impurity

CAS No: 2955712-44-2
Chemical Name:
6-acetyl-8-cyclopentyl-5-methyl-2-(5-(4-nitrosopiperazin-1-yl)pyridin-2-ylamino)pyrido[2,3-d]pyrimidin-7(8H)-one
Molecular Formula:
C24H28N8O3

Impurity-6

CAS No: 775288-71-6
Chemical Name:
1-(6-nitropyridin-3-yl)piperazine
Molecular Formula:
C9H12N4O2

Impurity-3

CAS No: 1956322-95-4
Chemical Name:
5-(piperazin-1-yl)pyridin-2-amine hydrochloride
Molecular Formula:
C9H15ClN4

Impurity-5

CAS No: 571189-16-7
Chemical Name:
tert-butyl 4-(6-nitropyridin-3-yl)piperazine-1-carboxylate
Molecular Formula:
C14H20N4O4

Impurity-4

CAS No: 571188-59-5
Chemical Name:
tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate
Molecular Formula:
C14H22N4O2

N-Hydroxy impurity

CAS No: 2231085-26-8
Chemical Name:
6-acetyl-8-cyclopentyl-2-(5-(4-hydroxypiperazin-1-yl)pyridin-2-ylamino)-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one
Molecular Formula:
C24H29N7O3

N-Formyl impurity

CAS No: 2174002-16-3
Chemical Name:
4-(6-(6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-ylamino)pyridin-3-yl)piperazine-1-carbaldehyde
Molecular Formula:
C25H29N7O3

   Lactose Adduct 

CAS No: NA
Chemical Name:
6-acetyl-8-cyclopentyl-2-(5-(4-((3R,4R,5S,6R)-3,4-dihydroxy-6-(hydroxymethyl)-5-((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yloxy)tetrahydro-2H-pyran-2-yl)piperazin-1-yl)pyridin-2-ylamino)-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one
Molecular Formula:
C36H49N7O12

Desoxo Boc Palbociclib

CAS No: NA
Chemical Name:
tert-butyl 4-(6-(8-cyclopentyl-5-methyl-7-oxo-6-vinyl-7,8-dihydropyrido[2,3-d]pyrimidin-2-ylamino)pyridin-3-yl)piperazine-1-carboxylate
Molecular Formula:
C29H37N7O3

6-deacetyl-6-bromo impurity

CAS No: NA
Chemical Name:
6-bromo-8-cyclopentyl-5-methyl-2-(5-(piperazin-1-yl)pyridin-2-ylamino)pyrido[2,3-d]pyrimidin-7(8H)-one
Molecular Formula:
C22H26BrN7O

6-deacetyl-6-bromo boc impurity

CAS No: NA
Chemical Name:
tert-butyl 4-(6-(6-bromo-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-ylamino)pyridin-3-yl)piperazine-1-carboxylate
Molecular Formula:
C27H34BrN7O3

Desacetyl N-BOC Analog

CAS No: 571189-65-6
Chemical Name:
tert-butyl 4-(6-(8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-ylamino)pyridin-3-yl)piperazine-1-carboxylate
Molecular Formula:
C27H35N7O3

Impurity-2

CAS No: 866084-31-3
Chemical Name:
tert-butyl 4-(6-(6-(1-butoxyvinyl)-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-ylamino)pyridin-3-yl)piperazine-1-carboxylate
Molecular Formula:
C33H45N7O4

Impurity-1

CAS No: 2206135-30-8
Chemical Name:
tert-butyl 4,4'-(6,6'-(8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2,6-diyl)bis(azanediyl)bis(pyridine-6,3-diyl))dipiperazine-1-carboxylate
Molecular Formula:
C41H55N11O5

6-Acetaldehyde Analog

CAS No: 2204368-66-9
Chemical Name:
2-(8-cyclopentyl-5-methyl-7-oxo-2-(5-(piperazin-1-yl)pyridin-2-ylamino)-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl)acetaldehyde
Molecular Formula:
C24H29N7O2

Pyridine N-Oxide

CAS No: 2098673-40-4
Chemical Name:
2-(6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-ylamino)-5-(piperazin-1-yl)pyridine 1-oxide
Molecular Formula:
C24H29N7O3

      Piperazine N-Oxide

CAS No: 2174002-29-8
Chemical Name:
1-(6-(6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-ylamino)pyridin-3-yl)piperazine 1-oxide
Molecular Formula:
C24H29N7O3

Reference standared

CAS No: 571190-30-2 827022-32-2 (HCl salt) ; 1985666-03-2 (HBr salt)
Chemical Name:
6-Acetyl-8-cyclopentyl-5-methyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]pyrido[2,3-d]pyrimidin-7(8H)-one
Molecular Formula:
C24H29N7O2

Acetyl Boc impurity

CAS No: 1651214-74-2
Chemical Name:
tert-butyl 4-(6-(6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-ylamino)pyridin-3-yl)piperazine-1-carboxylate
Molecular Formula:
C29H37N7O4

Desoxo Palbociclib

CAS No: 2204863-06-7
Chemical Name:
8-cyclopentyl-5-methyl-2-(5-(piperazin-1-yl)pyridin-2-ylamino)-6-vinylpyrido[2,3-d]pyrimidin-7(8H)-one
Molecular Formula:
C24H29N7O

Deacetyl impurity

CAS No:  571190-22-2
Chemical Name:
8-cyclopentyl-5-methyl-2-(5-(piperazin-1-yl)pyridin-2-ylamino)pyrido[2,3-d]pyrimidin-7(8H)-one
Molecular Formula:
C22H27N7O